This article focuses on wound healing. You can follow along with our Fundamentals of Nursing flashcards, which are intended to help RN and PN nursing students study for nursing school exams, including the ATI, HESI, and NCLEX.
Phases of wound healing
There are four phases of wound healing. These apply no matter the size of the wound. The phases of wound healing are: hemostasis, inflammatory, proliferation, and maturation. The duration of each phase may differ, depending on the type of wound, but all wounds have these phases in common.
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Hemostasis
The first phase is hemostasis. “Hemo” means blood. “Stasis” means stop. So, the goal of hemostasis is to stop the bleeding.
This is accomplished through the process of vasoconstriction, which is when the muscles around the blood vessels tighten to make the space inside smaller, and by activating the platelets in the blood, which trigger the “clotting cascade” (a series of clotting factors that activate one after the other) to stop the bleeding.
Inflammatory
Hemostasis is followed by the inflammatory phase. The goal of this phase is a clean wound. This phase may last several days.
Inflammation allows for the influx of white blood cells (neutrophils and macrophages) to eliminate bacteria and prevent infection. This is achieved through a process called diapedesis, the passage of blood cells through the capillary walls. Diapedesis is accomplished by vasodilating the capillaries, the opposite of vasoconstriction. So in this process, the capillaries are rendered “leaky,” which allows the neutrophils to seep through the capillary walls to do their work.
Inflammation is a normal part of the wound healing process — to an extent. Diapedesis will cause swelling, edema, and pain. It will be important to monitor the patient in the event remediation is required for any of these symptoms during this phase of wound healing.
Proliferation
The next phase of wound healing is the proliferation phase, whose goal is to fill and cover the wound. This phase introduces fibroblasts, which form granulation (or new) tissue. A fibroblast is a common type of cell found in connective tissue that plays a key role in healing wounds. With granulation, new blood vessels develop (known as angiogenesis). The wound contracts, and epithelial cells migrate to cover the wound bed.
Maturation
The last phase is known as maturation. The goal of maturation is to remodel the scar tissue. This can take a long time, up to a year or more.
In this phase, one type of collagen (type 3) is replaced by stronger collagen (type 1). Collagen is a structural protein that plays an essential protective role in the human body.
Intention
When discussing the healing process, we talk about healing by intention — primary, secondary, and tertiary intention. Literally, this means the first, second, and third way of doing something.
Primary intention
When a wound is healed by primary intention, the edges of the wound are approximated, which means they are brought together — they touch. Following a surgical incision, for example, the edges of the incision are approximated. That is, they are brought together using surgical sutures or staples. A paper cut heals by primary intention (we use a Band-Aid to approximate the edges of the cut).
Secondary intention
When a wound is healed by secondary intention, it is left open to heal through granulation, contraction, and epithelialization. This is “healing from the inside out” and takes longer than wound healed by primary intention.
An example of a wound healed by secondary intention is a pressure injury — an injury where the edges cannot be approximated and that must heal from the inside out.
Note that there is a higher risk of infection when healing times are longer.
Tertiary intention
Tertiary intention is when the closure of a wound is delayed — the wound is left open in order to irrigate, debride (thoroughly clean), and observe it (usually for about a week), before closing it surgically once the risk of infection is lower.
Complications of wound healing
Complications of wound healing may include:
- Hemorrhage: bleeding from a damaged blood vessel
- Infection
- Dehiscence: the total or partial separation of wound layers, that is, when a previously closed wound opens again
- Evisceration: dehiscence with organs protruding
Evisceration is a true medical emergency and the patient requires immediate surgical intervention.
In the event of evisceration, do not try to reinsert the organs. Place a saline-moistened gauze over the open area, lower the head of the bed (possibly put the patient in the Trendelenburg position), notify the provider immediately, and maintain patient NPO (null per os, i.e., the patient should fast) in anticipation of surgical repair.
Barriers to healing
There are many barriers to healing, including chronic illnesses (e.g., diabetes, which can impede circulation), smoking, malnutrition (especially insufficient protein), older age, impaired circulation (e.g., peripheral arterial disease), immunosuppression (having a weakened immune system), and corticosteroids (which can cause immune suppression).
Drainage
Wound drainage is a normal part of the healing process, though some types of drainage may indicate an infection. When changing the dressing of a wound and assessing its drainage, keep in mind the question, “Is what I’m seeing normal?”
Types of drainage
The different types of drainage include:
- Serous drainage: clear, watery drainage, which is normal
- Serosanguineous: serous fluid mixed with blood, which appears light pink and/or blood-tinged
- Sanguineous: bloody drainage that is bright red
- Purulent: looking like pus. This wound’s drainage is cloudy and could be white, yellow, or beige. It is malodorous (bad smelling). This indicates an infection is present.
Amount of drainage
Another thing to observe is the amount of drainage, which may be described as scant, small, moderate, large, or copious. Scant indicates a slightly moist wound with no exudate (pus) and, at the other end of the scale, copious, where the wound tissue is filled with fluid, and more than 75% of the bandage is covered in exudate.
Wound appearance
In addition to the amount and type of drainage of a wound, a wound’s appearance can indicate how it is healing.
Red
A wound that appears red indicates healthy tissue and good circulation. The wound has a “beefy” red color. Continue to protect the wound site and maintain a moist wound healing environment.
Yellow
A wound that appears yellow indicates the wound needs cleaning. The wound contains slough (necrotic tissue, which may look like “chicken fat”) and/or has purulent drainage (pus). This wound must be irrigated and cleaned.
Black
A wound that appears black indicates a wound that requires debridement. The wound contains eschar (hard or rubbery black/brown necrotic tissue) and needs autolytic debridement (using the body’s enzymes and natural fluids to soften bad tissue for its removal), enzymatic debridement (the application of a prescribed topical agent that chemically liquefies necrotic tissues with enzymes), chemical debridement (using enzymatic chemicals on the wound to cause lysis (breaking down) of the necrotic tissue in the wound), or sharp debridement (the use of scalpels, scissors, sharp curettes, or forceps to excise the necrosis from a wound bed).